Science and Systems
Colonix Medical's scientific methods are the result of extensive research, development and refinement, not to mention exhaustive quality assurance and regulatory considerations.
Colonix cannot divulge sensitive details of this methodology here, but here is an overview that gives a reasonable understanding of some of Colonix Medical's™ science and systems.
Cell Exfoliation
Scheme of cell exfoliation changes during colorectal carcinogenesis.
A. Physiological conditions - low exfoliation
B. Benign tumour (small polyp) - low exfoliation (possibly slightly higher than normal).
C. Malignisation/early cancer – increased exfoliation (change of apoptosis/exfoliation ratio)
D. Invasive cancer – highly increased exfoliation (free cells and blood also present).
Figure A.
Physiological conditions - low exfoliation
Figure B.
Benign tumour (small polyp) - low exfoliation (possibly slightly higher than normal)
Figure C.
Malignisation/early cancer – increased exfoliation (change of apoptosis/exfoliation ratio)
Figure D.
Invasive cancer – dramatically increased exfoliation (free cells and blood also present)
It should be understood that the scheme does not reflect the complexity of the
structure of colorectal mucosa (epithelium is shown as a simple monolayer
without crypts, blood vessels as straight tubes etc). Likewise, the presence of
apoptotic cells and cell debris that should be abundant in the mucocellular
layer is not shown.
These diagrams are taken from ‘Loktionov A. Cell exfoliation in the human colon myth, reality and implications for colorectal cancer screening. Review. Int.J.Cancer, 2007, vol 120 iss 11_ pp. 2281-2289’, a copy of which is available from the Press Downloads and Links page of this website.
